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學系成員

李弘霖 助理教授

  • 學歷
    國立中央大學化材系博士 (2018)
    經歷
    ◾麻省理工學院化工系 博士後研究員 (2023.07-2024.07)
    ◾國立中央大學化材系 博士後研究員 (2019.09-2023.07)
    ◾中原大學生物科技系 博士後研究員 (2019.04-2019.07)
    ◾St. John's University, College of Pharmacy and Health Sciences 訪問學者 (2016.04-2016.11)
    研究專長
    1.小分子藥物結晶
    2.製藥工程
    3.結晶製程開發
    4.同質多晶
    5.金屬有機架構材料
    6.連續式製程
    7.塑膠化學回收
    8.分離與純化

    1. Lee, H. L.; Chang, Y. W.; Hsiao, Y.-T.; Yeh, K. L.; Lee, T. Size Enlargement by Semibatch Reactive Crystallization with Varying Reactant Addition Methods and Reaction Kinetics: The Study of Dicumarol. Chem. Eng. Res. Des. 2024, 208, 740-752.

    2. Zimmermann, L.; Lee, H. L.; Koishybay, A.; Vlaar, C. P.; Monbaliu, J.-C. M.; Romañach, R. J.; Noor-E-Alam, Md. Myerson, A. S.; Stelzer, T. Measurements and Correlation of Timolol Maleate Solubility in Bio-based Neat and Binary Solvent Mixtures. J. Chem. Eng. Data 2024, 69 (6), 2369-2379.

    3. Wang, J. C.; Lee, H. L.; Pratama, D. E.; Lee, T. Accelerating the Drying Process by Spherical Agglomeration: The Case of Benzoic Acid. Ind. Eng. Chem. Res. 2023, 62 (51), 22028-22042.

    4. Lee, T.; Mo, J.-Y.; Pratama, D. E.; Lee, H. L.; Chen, Y.-H.; Huang, Y.-H.; Henríquez, L. C.; Corvis, Y. Preparation of Nanosized Clusters of Irinotecan Hydrochloride Trihydrate for Injection Concentrate to Reduce Carbon Footprint. Int. J. Pharm. 2023, 648, 123558.

    5. Lee, T.; Peng, Y.-K.; Lee, H. L.; Pratama, D. E. Chemical Recycling Development of Poly(ethylene terephthalate) by Glycolysis and Cooling Crystallization with Water. Ind. Eng. Chem. Res. 2023, 62 (46), 19873-19883.

    6. Vasoya, J. M.; Lee, H. L.; Lee, T.; Serajuddin, A. T. M. Continuous Synthesis of Cinnarizine Salt with Malic Acid by Applying Green Chemistry Using Water-Assisted Twin Screw Extrusion. Mol. Pharm. 2023, 20 (10), 5160-5172.

    7. Lee, H. L.; Yang, C. L.; Lee, T. Correction: Shaping Particle Size Distribution of a Metastable Polymorph in Additive-assisted Reactive Crystallization by the Taguchi Method. CrystEngComm 2023, 25 (4), 692.

    8. Lee, H. L.; Hung, Y. L.; Amin, A.; Pratama, D. E.; Lee, T. Green and Strategic Approach for Chiral Resolution by Diastereomeric Salt Formation: The Study of Racemic Ibuprofen. Ind. Eng. Chem. Res. 2023, 62 (4), 1946-1957.

    9. Tseng, Z. H.; Lee, H. L.; Wu, S. Y.; Yeh, K. L.; Lee, T. Development of Sustainable Reaction and Separation Processes for Amantadine and Amantadine Hydrochloride. Chem. Eng. Res. Des. 2022, 188, 393-405.

    10. Lee, H. L.; Yang, C. L.; Lee, T. Shaping Particle Size Distribution of a Metastable Polymorph in Additive-assisted Reactive Crystallization by the Taguchi Method. CrystEngComm 2022, 24 (40), 7176-7192.

    11. Yeh, K.-L.; Lee, H.-L.; Lee, T. Crystallization of Form II Paracetamol with the Assistance of Carboxylic Acids toward Batch and Continuous Processes. Pharmaceutics 2022, 14 (5), 1099.

    12. Lee, T.; Lee, H. L.; Yang, C. L. Saving Energy upon Water Removal in Drying by Making the α-Polymorph of L-Glutamic Acid. Sep. Sci. Technol. 2022, 57 (12), 1948-1965.

    13. Tseng, J. D.; Lee, H. L.; Yeh, K. L.; Lee, T. Recyclable Positive Azeotropes for the Purification of Curcumin with Optimum Purity and Solvent Capacity. Chem. Eng. Res. Des. 2022, 180, 200-211.

    14. Hsueh, J.-C.; Yeh, K. L.; Lee, H. L.; Lee, T. Strategy for Polymorphic Control by Enzymatic Reaction and Antisolvent Crystallization: Effect of Aminoacylase on Metastable β-Glycine Formation. React. Chem. Eng. 2021, 6 (12), 2292-2305.

    15. Chen, C. W.; Lee, H. L.; Yeh, K. L.; Lee, T. Effects of Scale-up and Impeller Types on Spherical Agglomeration of Dimethyl Fumarate. Ind. Eng. Chem. Res. 2021, 60 (30), 11555-11567.

    16. Lee, H. L.; Cheng, Y. S.; Yeh, K. L.; Lee, T. A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process. ACS Omega 2021, 6 (24), 15770-15781.

    17. Lee, H. L.; Chiu, C. W.; Lee, T. Engineering Terephthalic Acid Product from Recycling of PET Bottles Waste for Downstream Operations. Chem. Eng. J. Adv. 2021, 5, 100079.

    18. Pratama, D. E.; Hsieh, W.-C.; Elmaamoun, A.; Lee, H. L.; Lee, T. Recovery of Active Pharmaceutical Ingredients from Unused Solid Dosage-Form Drugs. ACS Omega 2020, 5 (45), 29147-29157.

    19. Chen, T.-H.; Yeh, K. L.; Chen, C. W.; Lee, H. L.; Hsu, Y. C.; Lee, T. Mixing Effect on Stoichiometric Diversity in Benzoic Acid-Sodium Benzoate Co-crystals. Cryst. Growth Des. 2019, 19 (3), 1576-1583.

    20. Wang, C. L.; Yeh, K. L.; Chen, C. W.; Lee, Y.; Lee, H. L.; Lee, T. A Quick-Fix Design of Phase Change Material by Particle Blending and Spherical Agglomeration. Appl. Energy 2017, 191, 239-250.

    21. Lee, H. L.; Vasoya, J. M.; de Lima Cirqueira, M.; Yeh, K. L.; Lee, T.; Serajuddin, A. T. M. Continuous Preparation of 1:1 Haloperidol-Maleic Acid Salt by a Novel Solvent-Free Method Using a Twin Screw Extruder. Mol. Pharm. 2017, 14 (4), 1278-1291.

    22. Lee, T.; Chang, Y. H.; Lee, H. L. Crystallization Process Development of Metal-Organic Frameworks by Linking Secondary Building Units, Lattice Nucleation and Luminescence: Insight Reproducibility. CrystEngComm 2017, 19 (3), 426-441.

    23. Lee, T.; Tsai, Y. C.; Lee, H. L.; Lin, T. Y.; Chang, Y. H. Metal-Organic Framework Engineering: Directed Assembly from Molecules to Spherical Agglomerates. J. Taiwan Inst. Chem. Eng. 2016, 62, 10-20.

    24. Lee, T.; Lin, T. Y.; Lee, H. L.; Chang, Y. H.; Tsai, Y. C. Biomimetic Taste Receptors with Chiral Recognition by Photoluminescent Metal-Organic Frameworks Chelated with Polyaniline Helices. Chem. Eur. J. 2016, 22 (4), 1406-1414.

    25. Chih, M. H.; Lee, H. L.; Lee, T. The Culprit of Gout: Triggering Factors and Formation of Monosodium Urate Monohydrate. CrystEngComm 2016, 18 (2), 290-297.

    26. Lee, H. L.; Lee, T. Direct Co-crystal Assembly from Synthesis to Co-crystallization. CrystEngComm 2015, 17 (47), 9002-9006.

    27. Lin, P. Y.; Lee, H. L.; Chen, C. W.; Lee, T. Effects of Baffle Configuration and Tank Size on Spherical Agglomerates of Dimethyl Fumarate in a Common Stirred Tank. Int. J. Pharm. 2015, 495 (2), 886-894.

    28. Lee, T.; Lee, Y.; Lee, H. L.; Syue, Y. R.; Chiu, Y. H.; Liou, J.-Y.; Sun, Y.-S. Bio-inspired Phase Change Materials Designed for High Specific Heat of Solid Phase. Thermochim. Acta 2014, 591, 61-67.

    29. Lee, H. L.; Lin, H. Y.; Lee, T. Large-Scale Crystallization of a Pure Metastable Polymorph by Reaction Coupling. Org. Proc. Res. Dev. 2014, 18 (4), 539-545.

    30. Lee, T.; Chiu, Y. H.; Lee, Y.; Lee, H. L. Thermal Properties and Structural Characterizations of New Types of Phase Change Material: Anhydrous and Hydrated Palmitic Acid/Camphene Solid Dispersions. Thermochim. Acta 2014, 575, 81-89.

    31. Lee, H. L.; Lee, T. Current Technologies and Future Trends in Ammonium Nitrate. In Ammonium Nitrate: Synthesis, Chemical Properties and Health Hazards, Rivera, D. C., Eds.; Nova Science Publishers, Inc.: NY, USA, 2014; 87-110 (Book Chapter).

    32. Lee, T.; Lin, H. Y.; Lee, H. L. Engineering Reaction and Crystallization and the Impact on Filtration, Drying, and Dissolution Behaviors: The Study of Acetaminophen (Paracetamol) by In-Process Controls. Org. Proc. Res. Dev. 2013, 17 (9), 1168-1178.

    33. Lee, T.; Lin, Y. K.; Tsai, Y. C.; Lee, H. L. Propagation of Biochirality: Crossovers and Nonclassical Crystallization Kinetics of Aspartic Acid in Water. Chirality 2013, 25 (11), 768-779.

    34. Lee, T.; Chen, J. W.; Lee, H. L.; Lin, T. Y.; Tsai, Y. C.; Cheng, S.-L.; Lee, S.-W.; Hu, J.-C.; Chen, L.-T. Stabilization and Spheroidization of Ammonium Nitrate: Co-crystallization with Crown Ethers and Spherical Crystallization by Solvent Screening. Chem. Eng. J. 2013, 225, 809-817.

    35. Lee, T.; Lee, H. L.; Tsai, M. H.; Cheng, S.-L.; Lee, S.-W.; Hu, J.-C.; Chen, L.-T. A Biomimetic Tongue by Photoluminescent Metal-Organic Frameworks. Biosens. Bioelectron. 2013, 43, 56-62.

    36. Lee, T.; Chen, H. L.; Lin, H. Y.; Lee, H. L. Continuous Co-crystallization as a Separation Technology: The Study of 1:2 Co-crystals of Phenazine-Vanillin. Cryst. Growth Des. 2012, 12 (12), 5897-5907.

    37. Lee, T.; Tsai, M. H.; Lee, H. L. Riboflavin Chelated Luminescent Metal-Organic Framework: Identified by Liquid-Assisted Grinding for Large-Molecule Sensing via Chromaticity Coordinates. Cryst. Growth Des. 2012, 12 (6), 3181-3190.

    38. Lee, T.; Liu, Z. X.; Lee, H. L. A Biomimetic Nose by Microcrystals and Oriented Films of Luminescent Porous Metal-Organic Frameworks. Cryst. Growth Des. 2011, 11 (9), 4146-4154.

    1. 林宏祐、李弘霖、蔡孟勳、薛喻仁、陳鑫榮、蔡雅鈞、邱鈺秀、謝宥晟、李度*。結晶工程在綠色科技上的應用。化工技術，2012，20 (12)，79-89。

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